KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.038 | - |
1,2-didecanoyl-1-thioglycerol | 37°C, pH 7.4 | Bos taurus | |
0.055 | - |
1-stearoyl-2-arachidonoyl-sn-glycerol | 37°C, pH 7.4 | Bos taurus | |
0.063 | - |
1-stearoyl-2-arachidonoyl-sn-glycerol | 37°C, pH 7.4 | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Bos taurus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27000 | - |
x * 27000, SDS-PAGE | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bos taurus | diacylglycerol lipase may regulate protein kinase C activity and 2-arachidonoyl-sn-glycerol levels by rapidly altering the intracellular concentration of diacylglycerols | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | Q2KI18 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation by cAMP-dependent protein kinase results in a three-fold increase in catalytic thrpoughput | Bos taurus |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-didecanoyl-1-thioglycerol + H2O | - |
Bos taurus | ? | - |
? | |
1-stearoyl-2-arachidonoyl-sn-glycerol + H2O | - |
Bos taurus | ? | - |
? | |
additional information | diacylglycerol lipase may regulate protein kinase C activity and 2-arachidonoyl-sn-glycerol levels by rapidly altering the intracellular concentration of diacylglycerols | Bos taurus | ? | - |
? | |
additional information | 1,2-diacyl-sn-glycerols are the preferred substrates over 1,3-diacyl-sn-glycerols. The enzyme hydrolyzes stearate in preference to palmitate from the sn-1-position of 1,2-diacyl-sn-glycerols. 1-O-alkyl-2-acyl-sn-glycerols are not a substrate for the enzyme | Bos taurus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 27000, SDS-PAGE | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
diacylglycerol lipase | - |
Bos taurus |